[8:25 PM] Cardinals @ 49ers

Who will WIN this matchup?

Arizona Cardinals (1-3)

@ San Francisco 49ers (1-3)

Current odds:

Arizona Cardinals: (-181)

San Francisco 49ers: (+161)

• ESPN simulations have Arizona as XX% favorites to win the game.

• XX% of sports bets are currently on Arizona to win as (XX) favorites.

• The line for this game is Cardinals by 3.5 points.

• The Arizona Cardinals have been plagued by turnovers of late and the trendy preseason Super Bowl pick temporarily could be faced with turning over the keys to backup quarterback Drew Stanton on Thursday when they visit the San Francisco 49ers. With veteran Carson Palmer considered day-to-day with a concussion, Stanton may be left looking to conjure the magic that saw him pull a 5-3 mark out of his hat during a stint in 2014.

• David Johnson (64 carries, 300 yards, three TDs) leads the NFL with 510 yards from scrimmage and has recorded 100 or more total yards in all four contests this season and eight of his last nine games. Johnson amassed 124 from scrimmage (83 rushing, 41 receiving) versus the Rams, but the workload was decidedly different in last year’s season series with San Francisco (15 carries, 46 yards). The 24-year-old will be spelled by Andre Ellington, as veteran Chris Johnson (groin) was placed on injured reserve Tuesday. Tyvon Branch was also shuffled to IR, with fellow safety Tyrann Mathieu temporarily being moved into the slot while D.J. Swearinger plays in nickel packages.

• San Francisco collected eight takeaways in its first three games to provide a helping hand for the NFL’s 28th-ranked offense, which scored a league-best 45 points off the turnovers after mustering an NFL-worst 25 for the entire 2015 season. The 49ers failed to force a turnover versus the Cowboys on Sunday and Blaine Gabbert’s fourth interception of the season ended his team’s bid for an upset. Carlos Hyde (73 carries, 299 yards, NFC-best five TDs) is averaging 4.9 yards per rush over his last two games, but was limited to just 51 yards in a 47-7 loss at Arizona on Sept. 27

• Arizona has yet to score in the first quarter this season and has been blanked over the first 15 minutes of a contest in six straight dating to 2015.

• San Francisco WR Jeremy Kerley, who had six receptions for 88 yards and a touchdown last week, leads the team in catches (18) and receiving yards (202.)

• Cardinals LBs Chandler Jones and Markus Golden each have recorded a sack in all four contests this season.

StreakSmarts Pick: Arizona Cardinals

Confidence: 4/10