Who will WIN this matchup?
San Francisco 49ers (1-7)
@ Arizona Cardinals (3-4)
Current odds:
San Francisco 49ers: (+638)
Arizona Cardinals: (-800)
• ESPN simulations have Arizona as 76.1% favorites to win the game.
• 67% of sports bets are currently on Arizona to win as (-800) favorites.
• San Francisco had hoped to come out of its bye week rejuvenated and halt its six-game losing streak, but it ran into a buzzsaw in Drew Brees and the New Orleans Saints en route to a 41-23 loss last Sunday. Colin Kaepernick will be looking to redeem himself after completing 9-of-19 passes for 67 yards with four interceptions – two returned for touchdowns – in a 47-7 loss in his last start at Arizona.
• Like the 49ers last week, the Cardinals are hoping to hit the ground running following their bye week after going 0-1-1 in their final two games before the break. Arizona can be optimistic about its chances as it enters Week 10 with a league-leading defense that is allowing 297 yards per game and the third-best passing defense (194.9). David Johnson, who ranks fourth in the NFL with 705 yards on the ground, could have a field day as San Francisco’s league-worst rushing defense is giving up 193 per contest.
• Kaepernick showed signs of his former self last week, passing for 398 yards and two touchdowns in a losing effort. He also ran for 23 yards, raising his career total of 2,005 to join Steve Young as the only quarterbacks in franchise history to reach the 2,000-yard plateau. Vance McDonald has registered two touchdowns of at least 65 yards this year, making him the fourth NFL tight end since 1970 and first since Shannon Sharpe in 1997 to do so in the one season.
• The injury bug continues to bite Arizona as it lost tackle Jared Veldheer to a torn biceps tendon and safety Tyrann Mathieu to a shoulder subluxation in its loss to Carolina in Week 8. The Cardinals, who hope to have Mathieu back in a week or two, also have 10 players on season-ending injured reserve. Johnson leads the NFC with eight rushing touchdowns and ranks first in the entire league with 1,112 yards from scrimmage, including a franchise-record streak of eight straight games with at least 100.
• Arizona has won four of its last five meetings with the 49ers, including a 33-21 victory at San Francisco in Week 5.
StreakSmarts Pick: Arizona Cardinals
Confidence: 7/10
•Coming Soon•
•Coming Soon•
•Coming Soon•
•Coming Soon•
•Coming Soon•
•Coming Soon•
•Coming Soon•
•Coming Soon•
•Coming Soon•
•Coming Soon•
•Coming Soon•
•Coming Soon•
 
Top Pick Record For September 2022: 78-14
Top Pick Record For August 2022: 48-12
Top Pick Record For July 2022: 37-9
Top Pick Record For June 2022: 31-14
Top Pick Record For May 2022: 40-15
Top Pick Record For April 2022: 48-11
Top Pick Record For March 2022: 122-29
Top Pick Record For February 2022: 92-34
Top Pick Record For January 2022: 98-18
Top Pick Record For December 2021: 103-24
Top Pick Record For November 2021: 86-32
Top Pick Record For October 2021: 74-20
Top Pick Record For September 2021: 75-25
Top Pick Record For August 2021: 43-17
Top Pick Record For July 2021: 28-9
Top Pick Record For June 2021: 43-11
Top Pick Record For May 2021: 61-18
Top Pick Record For April 2021: 51-15
Top Pick Record For March 2021: 152-37
Top Pick Record For February 2021: 60-28
Top Pick Record For January 2021: 55-23
Top Pick Record For December 2020: 47-23
Top Pick Record For November 2020: 24-5
Top Pick Record For October 2020: 21-5
Top Pick Record For September 2020: `41-12
Top Pick Record For August 2020: 32-8
Top Pick Record For July 2020: 11-5
Top Pick Record For June 2020: 2-0
Top Pick Record For May 2020: 5-1
Top Pick Record For April 2020: 7-2
Top Pick Record For March 2020: 13-3
Top Pick Record For February 2020: 13-4
Top Pick Record For January 2020: 17-4
Top Pick Record For December 2019: 22-7
Top Pick Record For November 2019: 21-7
Top Pick Record For October 2019: 14-4
Top Pick Record For September 2019: 22-2
 
Top Pick Record For NBA: 220-106
Top Pick Record For NFL: 84-18
Top Pick Record For MLB: 195-76
Top Pick Record For NHL: 127-43
Top Pick Record For College Football: 120-34
Top Pick Record For Men's College Basketball: 241-83
Top Pick Record For Women's College Basketball: 137-23
Top Pick Record For WNBA: 56-11
Top Pick Record For Soccer: 68-12
Top Pick Record For UFC: 2-0
Top Pick Record For Tennis: 45-11
Top Pick Record For Hockey: 6-0
Top Pick Record For Golf: 3-1
Top Pick Record For Olympics: 3-0
Top Pick Record For Boxing: 1-0
Top Pick Record For Baseball: 3-2
Top Pick Record For Softball: 7-3
Top Pick Record For Volleyball: 6-0
Top Pick Record For Other: 21-0
Top Pick Record For Hoops: 6-1
Top Pick Record For Television: 1-0
Top Pick Record For Eating: 3-0
Top Pick Record For Cricket: 1-0
Top Pick Record For Lacrosse: 4-0
Top Pick Record For Track & Field: 1-0
 
An update on the old Streak for the cash game formally run by ESPN: http://streakforthecash.com