[8:15 PM] #3 Louisville @ #5 Clemson

Who will WIN this matchup?

#3 Louisville Cardinals (4-0)

@ #5 Clemson Tigers (4-0)


Current odds:

Louisville Cardinals: (-118)

Clemson Tigers: (+105)


ESPN simulations have Clemson as 67.3% favorites to win the game.

52% of sports bets are currently on Louisville to win as (-118) favorites.

The Tigers’ defense dominated last year’s contest, holding the Cardinals to 272 total yards — and just 19 yards on the ground. Slowing down this year’s Louisville team will be a tough task, as the No. 4-ranked Cardinals lead the nation in scoring and total offense behind dual-threat quarterback Lamar Jackson.

No. 3 Clemson boasts a dangerous quarterback of its own in Deshaun Watson, who is 22-2 as a starter and ranks third on the Tigers’ all-time passing list.

Jackson is widely considered the runaway leader in the Heisman Trophy race, having accounted for 25 touchdowns (13 passing, 12 rushing) through four games.

If any team is up to the task of quieting the Cardinals’ offense, it might be the Tigers, who are coming off a dominant defensive effort after holding Georgia Tech to 124 total yards in a 26-7 victory.

Clemson has won 18 consecutive regular-season games, 18 straight home games and 10 straight against ACC opponents.

StreakSmarts Pick: #3 Louisville Cardinals

Confidence: 4/10

StreakSmarter Pick